Which Clinical Features Distinguish Nerve Large-Arteriole Vasculitis from Nerve Microvasculitis?

Although nonsystemic disease, proximal findings, and autonomic involvement were more characteristic of microvasculitis, there was substantial overlap in this large retrospective cohort.

Vasculitic neuropathy is classically described as having acute-to-subacute onset with multiple mononeuropathies. To elucidate clinical differences based on size of vessel involvement, investigators reviewed charts from all patients >10 years old with a pathologic diagnosis of nerve vasculitis at the Mayo Clinic. Vessel wall inflammation and either wall damage or destruction had to be present on nerve biopsy.

Of 278 patients evaluated over 19 years, 125 were diagnosed with large-arteriole vasculitis (affected vessels ≥75 µm) and 153 with nerve microvasculitis (<75 µm). Large-arteriole nerve vasculitis was more likely to present acutely (50% vs. 27%) and be associated with systemic vasculitis (77% vs. 29%) but was less often associated with di…

Reviewing Author

Leana Doherty, MD

Disclosures

Editorial BoardsNeurohospitalist Society; InterACTN (Annals of Clinical and Translational Neurology)

Leana Doherty, MD

Disclosures

Editorial BoardsNeurohospitalist Society; InterACTN (Annals of Clinical and Translational Neurology)

Which Clinical Features Distinguish Nerve Large-Arteriole Vasculitis from Nerve Microvasculitis?

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Reviewing Author