Collateral Effects of Doxycycline Postexposure Prophylaxis

After doxyPEP's rollout among high-risk populations, tetracycline resistance in Neisseria gonorrhoeae and other organisms rose quickly.

Although the CDC recommends doxycycline postexposure prophylaxis (doxyPEP) for preventing bacterial sexually transmitted infections (STIs) among men who have sex with men (MSM) and transgender persons (TGP), the possible consequences regarding antimicrobial resistance are cause for concern. To assess doxyPEP's effects on tetracycline resistance in Neisseria gonorrhoeae (NG), Staphylococcus aureus, and Group A Streptococcus (GAS), investigators analyzed data routinely collected by sexual health clinics from MSM and TGP before and after rollout of this intervention in the Seattle area.

Tetracycline resistance in N. gonorrhoeae rose from 27% to 70%. High-level resistance, once rare, jumped from 2% to 65%. Persons who took more than three doses …

Reviewing Author

Carlos del Rio, MD

Disclosures

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines

Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)

Carlos del Rio, MD

Disclosures

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines

Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)

Collateral Effects of Doxycycline Postexposure Prophylaxis

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Reviewing Author