Does COVID-19 Raise Risk for Posttransplant Diabetes Mellitus?

Contracting COVID-19 within 6 months of solid-organ transplantation increased the relative risk for developing diabetes mellitus by 37%.

Up to 40% of solid-organ transplant recipients (SOTR) will develop posttransplant diabetes mellitus (PTDM). While medications such as calcineurin inhibitors and corticosteroids contribute to this risk, viral infections such as cytomegalovirus have been associated with PTDM. Is COVID-19 also a risk factor for PTDM? To find out, investigators conducted a retrospective cohort study of adult SOTRs without diabetes who did or did not have a posttransplant diagnosis of COVID-19.

Among SOTRs with a COVID-19 diagnosis within 180 days of transplant, 17% developed PTDM within 2 years. By contrast, PTDM occurred in 13% of matched SOTRs without COVID-19 (hazard ratio for PTDM, 1.37). Additional risk factors for PTDM were lung transplantation, older age,…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Does COVID-19 Raise Risk for Posttransplant Diabetes Mellitus?

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Reviewing Author