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The 2019 ACC/AHA guideline on primary prevention of cardiovascular disease listed HIV as a “risk-enhancing factor” that might influence a decision to initiate statins. In 2023, the REPRIEVE trial demonstrated that statins could lower the incidence of adverse cardiovascular events significantly in people with HIV, even if they otherwise were at low risk for cardiovascular disease (CVD; NEJM JW Gen Med Sep 1 2023 and N Engl J Med 2023; 389:687). Those compelling…