Histoplasmosis and HIV in Sub-Saharan Africa

Histoplasma antigenuria occurred in one quarter of highly immunocompromised individuals who were evaluated for tuberculosis in Côte d'Ivoire.

With its worldwide distribution, histoplasmosis (caused by the fungus Histoplasma capsulatum) has been increasingly recognized as an important opportunistic infection among persons with HIV (PWH). French investigators hypothesized that undiagnosed histoplasmosis caused excess mortality in an anti-tuberculosis (TB) treatment trial enrolling highly immunocompromised (CD4 cell count <100/µL) PWH in Côte d'Ivoire. A subset of 293 participants with available urine samples and clinical data was evaluated for the presence of Histoplasma antigenuria using enzyme immunoassay.

Among these participants, prevalence of Histoplasma antigenuria was 24%, including 8 of 22 (36%) with simultaneously diagnosed TB. For the 42 who died within 48 weeks' follow-up…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Histoplasmosis and HIV in Sub-Saharan Africa

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Reviewing Author