New CDC Guidelines for HIV Nonoccupational Postexposure Prophylaxis

Integrase inhibitor–based regimens are recommended for 28 days after nonoccupational exposures.

Sponsoring Organization: Centers for Disease Control

Background and Objective

The CDC last issued guidelines for nonoccupational postexposure prophylaxis (nPEP) in 2016. Nonoccupational exposures range from sexual (including assaults) to needle-sharing during injection drug use, and are to be distinguished from occupational needle-stick injuries (which mostly involve healthcare professionals and have separate guidelines). Now, the CDC has updated its nPEP guidelines to include newer antiretroviral regimens and a revised testing schedule.

Key Recommendations

nPEP is recommended for persons who have sexual or needle-sharing exposure to a source with HIV who does not have sustained HIV suppression or whose suppression status is unknown.
If the sour…

Reviewing Author

Rajesh T. Gandhi, MD

Disclosures

Grant/Research SupportNIH

Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)

Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)