What Determines Long-Term Shedding of Non-Typhoidal Salmonella?

In a Norwegian study, risk factors for long-term pathogen shedding included regular use of medication, following a lactose-free diet, and Salmonella subtype.

Non-typhoidal Salmonella (NTS) infection in humans is usually self-limiting, with most infected people shedding NTS in the feces for only a few weeks; however, a minority may do so for prolonged periods. Previous studies found associations with symptomatic infection, NTS subtype, and the patient's age and antibiotic use, but clear evidence is lacking. Now, Norwegian researchers have prospectively assessed risk factors for prolonged NTS shedding. Among the 1094 NTS infections reported in 2019, about one-quarter of patients (or their parents) provided a second stool sample 5 weeks later and returned a questionnaire about potential risk factors.

The key results:

The most common symptoms during the initial infection were diarrhea, abdominal pain,…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

What Determines Long-Term Shedding of Non-Typhoidal Salmonella?

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Reviewing Author