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Hepatitis E virus (HEV) is a single-stranded RNA virus transmitted primarily via the fecal-oral route (before routine screening, blood products from viremic donors also occasionally transmitted the illness). Immunocompetent individuals usually experience HE as a mild, self-limited, often asymptomatic illness. However, immunocompromised patients can develop chronic symptomatic HE, leading to cirrhosis if untreated. Ribavirin is used to treat HE in immunocompromised patients, but it is associated with various adverse effects, including anemia, and the optimal regimen is unclear. To identify the ribavirin regimen with best sustained HEV elimination and fewest adverse effects, researchers retrospectively analyzed virologic and pharmacologic dat…