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The American College of Chest Physicians recommends targeting “core respiratory pathogens” (rather than resistant organisms) in immunocompromised patients with community-acquired pneumonia (CAP) who do not have risk factors for multidrug-resistant organisms (MDROs). In a retrospective cohort study, Michigan investigators compared patients who received broad-spectrum antibiotics (agents covering methicillin-resistant Staphylococcus aureus or pseudomonas or both) with those receiving guideline-recommended narrow-spectrum antibiotics (e.g., ceftriaxone with or without azithromycin or doxycycline). Severely immunocompromised patients and those meeting MDRO criteria (based on respiratory, blood, or nares culture within the past year) were exclud…