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Gastric infection with Helicobacter pylori initiates mucosal changes that can evolve to adenocarcinoma. Two new reports expand our understanding of the effect of H. pylori eradication on gastric cancer development.
Researchers conducted a meta-analysis of 11 randomized trials and 13 cohort studies that compared outcomes in treated and untreated H. pylori–positive adults. In both groups of studies, gastric cancer incidence was 40% lower in people who underwent H. pylori eradication. All but two of these studies were from eastern Asia.
In a retrospective study from Nordic countries (Denmark, Sweden, Norway, Finland, and Iceland), researchers tracked outcomes among 700,000 people treated for H. pylori infection. The incidence of gastric carcinom…