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The treatment of HIV infection is one of the most rapidly evolving fields in medicine. Advances in basic research, the development of new technologies for monitoring therapy, the continuous introduction of new drugs into clinical practice, and the dissemination of the results of recent trials all raise expectations and suggest new strategies for optimal management of HIV disease. It is clear that, as more antiretrovirals become available, clinicians will face more and more complex decisions on when to start antiretroviral treatment and with what combinations and, in the long term, how to define therapeutic failure.
Although analysis of the relation between drug resistance and treatment failure has in the past been complicated by concomitant …