Pathogenesis of Lipodystrophy

Four studies from the 2nd International Workshop on Adverse Drug Reactions and Lipodystrophy presented data on how antiretroviral therapy might alter the metabolism of adipocytes, contributing to some of the body-shape changes seen in HIV-associated lipodystrophy.

The morphologic and metabolic changes caused by the HIV-associated lipodystrophy syndrome have been well categorized; however, the pathogenesis of the syndrome (or syndromes) is far less well understood. Several posters at the Lipodystrophy meeting presented preliminary data about the pathogenesis of these body-shape changes.

Indinavir impairs adipocyte differentiation and induces insulin resistance, probably by altering ADD1/SREBP-1 maturation. In one study [abstr. 03] the 3T3-F442A preadipocyte cell line was cultured in the presence and absence of indinavir. Indinavir did not alter cell growth or insulin responsiveness, but did impair the first step of cell differentiation. However, indinavir did impair adipocyte differentiation by interfe…

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Christine Wanke, MD

Pathogenesis of Lipodystrophy

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