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Soon after the introduction of potent combination antiretroviral therapy in 1996, many clinicians observed that virologic response rates in clinical practice were lower than those reported in clinical trials. One of the first studies to document this was the Johns Hopkins HIV Cohort Study, in which about 40% of patients achieved an undetectable viral load after 1 year of treatment, compared with approximately 60% of patients in clinical trials at the same time (ACC Sep 1 1999). Now the Hopkins group has published follow-up data demonstrating that treatment outcomes have improved substantially in clinical practice. The report details virologic and immunologic outcomes in 1255 patients who started their first triple-combination regimen (two N…