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At a December 13, 2006, press conference, the NIH presented data from two studies — conducted in Kenya and Uganda — on adult male circumcision for the prevention of HIV infection (see press release). In both trials, healthy HIV-negative men were randomized to receive circumcision immediately or to wait 2 years. All men received HIV prevention counseling, and follow-up was extensive.
Both trials met enrollment targets by September 2005 and were supposed to continue through mid-2007. However, the results of an interim analysis by the Data and Safety Monitoring Board on December 12, 2006, were impressive enough to prompt early termination, and all men in the control groups are now being offered immediate circumcision. Among nearly 2800 voluntee…