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Given the potential role of insulin resistance in HIV-associated lipodystrophy, researchers have begun evaluating insulin-sensitizing drugs as possible treatment options. In this ACTG study, HIV-infected patients with hyperinsulinemia (either fasting or after 75-g glucose challenge) and increased waist-to-hip ratios (>0.95 for men, >0.85 for women) were randomized to receive metformin (500 mg twice daily for the first 2 weeks and then 1000 mg twice daily), rosiglitazone (4 mg daily), both, or double placebo. Although investigators originally planned to enroll 32 subjects in each arm, accrual was halted early, after the Data and Safety Monitoring Board reviewed data from the first 98 subjects and concluded that further recruitment would not …