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The prognosis of HIV-infected patients is a moving target, because of both the dramatic changes in treatment that occurred in the mid-1990s and the improved responses to therapy over time (ACC May 7 2007 and Jul 27 2005). Here, investigators from the largest collaborative HIV cohort study provide an update to their risk calculator, reporting the incidence of AIDS or death 5 years after starting antiretroviral therapy (ART). They examined both baseline characteristics and 6-month response to therapy.
The ART Cohort Collaboration, established in 2000, collects data from 12 prospective cohort studies in Europe and North America. This particular analysis included data from 20,379 patients (76% men) who began ART between 1995 and 2003. Forty perc…