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Despite some progress, anti-HIV microbicides have generally yielded disappointing results, and the studies presented at this year’s IAS Conference on HIV Pathogenesis, Treatment and Prevention were no exception.
As previously reported, two phase III, randomized, placebo-controlled trials of cellulose sulfate were stopped earlier this year, after one of the trials showed an increased incidence of HIV infection among women using the investigational compound (ACC Feb 12 2007). Now, researchers have provided more details about those trials.
The CONRAD study took place in Africa and India and involved 1428 HIV-uninfected women (mean age, 30) who had multiple sex partners [Abstract WESS301]. At baseline, study participants reported hav…