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After all these years, Pneumocystis jiroveci pneumonia (PCP) is still the most common AIDS-associated opportunistic infection and, even with treatment, is life-threatening for some patients. To evaluate trends in mortality and early predictors of death, investigators reviewed data from 494 HIV-infected patients who were admitted to a London hospital with laboratory-confirmed PCP between 1985 and 2006. The only potential predictors of mortality assessed in this analysis were those present at admission or soon thereafter; those that occurred during hospitalization, such as ventilatory failure or development of pneumothorax, were not considered.
Forty-seven patients had multiple episodes of PCP during the study, for a total of 547 PCP-related a…