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Most studies of antiretroviral use and risk for myocardial infarction (MI) have focused on PI use. However, as reported at the 15th Retrovirus Conference, investigators with the DAD Study uncovered some surprising results while analyzing the potential of NRTIs to increase MI risk [Abstract 957c]. Their initial hypothesis was that increased risk would be associated with thymidine analogues. Instead, they found that recent use of abacavir and ddI were each independently associated with increased MI risk (relative risks, 1.9 and 1.5, respectively), even after adjustment for viral load, CD4-cell count, dyslipidemia, and other metabolic factors. Risk accrued quickly after initiation of these drugs and disappeared within 6 months after discontinu…