Emergence of the K65R Mutation with NNRTI-Based Regimens

In the Swiss HIV Cohort Study, emergence of the K65R mutation was significantly associated with tenofovir-containing regimens that were anchored by NNRTIs rather than by PIs.

According to the latest HIV treatment guidelines from the U.S. Department of Health and Human Services, tenofovir/FTC plus efavirenz is one of the preferred antiretroviral regimens for treatment-naive patients. However, concerns have been raised recently about the emergence of the K65R mutation and subsequent tenofovir resistance in patients who receive this regimen.

In this retrospective analysis from the Swiss HIV Cohort Study, investigators reviewed data from all patients who had genotypic resistance tests performed while they were receiving tenofovir. The K65R mutation was associated with concomitant ddI use, presumably because both drugs select for this mutation. Furthermore, some thymidine-analogue mutations, such as D67N, K70R, T215F,…

Reviewing Author

Manish Sagar, MD

Emergence of the K65R Mutation with NNRTI-Based Regimens

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Reviewing Author