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A number of studies in recent years have demonstrated that people with HIV infection have an increased risk not only for AIDS-defining cancers but also for several non–AIDS-defining ones (AIDS Clin Care May 12 2008). In the latest such study, investigators describe the incidence of cancer in two large cohorts of HIV-infected patients in the U.S., compared with the general population, from 1992 through 2003. Data from the two cohorts (the Adult and Adolescent Spectrum of HIV Disease Project and the HIV Outpatient Study) were similar and so were combined for these analyses.
Of the 3550 incident cancers identified among HIV-infected patients during 157,819 person-years of observation, 20% were not AIDS-defining. Compared with the general U.S. p…