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In the ongoing search for the “best” initial antiretroviral combination, comparing the failure rates of different regimens is not enough. The reasons for failure are also important, because the resistance patterns that are created when initial antiretroviral treatment fails have powerful implications for the success of future treatments. In the present study (a meta-analysis), researchers assessed the differences between resistance patterns created by failed boosted PI–based combinations and those created by failed NNRTI-based combinations.
Twenty clinical trials were included in the analysis, yielding information on more than 7000 individuals who initiated antiretroviral therapy with either a boosted PI or an NNRTI, along with 3TC, FTC, and…