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Despite effective HIV treatment, the neurologic syndrome once classified as the AIDS dementia complex is still a clinical entity, and neurologists now are attempting to redefine the components of that diagnosis. One part of that effort addresses the prevalence and nature of motor function abnormalities within the syndrome.
Motor strength, tone, reflexes, coordination, and gait were rigorously assessed in 237 HIV-infected patients (mean age, 50) as part of a large, prospective study of HIV-associated neurologic abnormalities. Most patients were receiving combination antiretroviral therapy, most patients were current or former drug users, and nearly 40% had prior trauma to the central nervous system. Seventy-two patients had no motor impairmen…