Cardiovascular Biomarkers and All-Cause Mortality in HIV-Infected Patients

High levels of hsCRP and D-dimer were associated with mortality risk in the SMART study. Patients who interrupted antiretroviral therapy experienced immediate increases in biomarker levels that were related to increases in viral load.

Previous studies have suggested that HIV-positive patients have higher levels of some inflammatory and coagulation markers than do HIV-negative patients — a finding that could at least partially explain the higher rates of non–AIDS-related morbidity and mortality observed among HIV-positive patients. However, no prospective data have been available to elucidate an association between such biomarkers and all-cause mortality in HIV-positive patients. To fill this gap, investigators conducted two substudies within the SMART trial, looking at high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, amyloid A, amyloid P, D-dimer, and prothrombin fragment 1+2.

In the first substudy, the researchers assessed baseline biomarker levels and su…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Cardiovascular Biomarkers and All-Cause Mortality in HIV-Infected Patients

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Reviewing Author