Changing Trends in Cancer Incidence Among HIV-Infected Patients

A 20-year cohort study of HIV-infected patients suggests that the rate of non-AIDS-defining cancers is increasing, likely because of longer life spans.

Some studies have shown marked changes in the incidence of cancer among HIV-infected patients since the advent of potent antiretroviral therapy (ART) — in particular, that the rates of certain AIDS-defining cancers (Kaposi sarcoma and non-Hodgkin lymphoma) have declined and that non–AIDS-defining malignancies account for an increasing proportion of cancer cases. To evaluate these trends further, investigators analyzed data collected prospectively from 4498 HIV-infected U.S. military beneficiaries (91% men) between 1984 and 2006. Three quarters of the patients received their HIV diagnoses before 1996. At the time of diagnosis, median age was 28 and median CD4 count was 510 cells/mm³ (only 5.7% had CD4 counts <200 cells/mm³).

A total of 446 pa…

Reviewing Authors

Deepa Reddy, MD

Carlos del Rio, MD

Disclosures

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines

Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)

Carlos del Rio, MD

Disclosures

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines

Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)

Changing Trends in Cancer Incidence Among HIV-Infected Patients

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Reviewing Authors