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Twenty-five years into the HIV/AIDS epidemic, the search for safe and effective HIV prevention methods continues. Much hope now rests on antiretrovirals for preexposure prophylaxis (PrEP). Several clinical trials are currently under way to assess the efficacy of this intervention:
A CDC study investigating oral tenofovir among intravenous-drug users in Thailand
A USAID-funded study of 1% tenofovir gel among high-risk women in South Africa
Three trials of coformulated oral tenofovir/FTC (Truvada): a CDC study among high-risk men and women in Botswana; a Gates Foundation–funded study among serodiscordant heterosexual couples in Kenya and Uganda; and an NIH-funded study among men who have sex with men in South Africa, Peru, Ecuador, Brazil, and t…