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Investigators from the MACS cohort have previously noted that advanced AIDS and aging share many common features, including both immunologic and physical changes. In particular, they have suggested that frailty in healthy elders is similar to the AIDS wasting syndrome.
Now, these investigators have evaluated the prevalence and predictors of frailty among more than 1000 HIV-infected men who were followed in the MACS cohort from mid-1994 through mid-2005. Four components of frailty — slowness, exhaustion, low physical activity level, and weight loss — were assessed by questionnaire at routine study visits. Frailty was defined as the presence of at least three of these four components at a single visit.
When investigators evaluated only those st…