Mixed Effect of ART on CVD Markers

In a small randomized trial, boosted PI–based regimens improved several markers of endothelial function but increased carotid intima-media thickness and decreased arterial elasticity.

Both HIV infection and potent combination antiretroviral therapy (ART) have been linked to excess risk for cardiovascular disease (CVD). In the present study, investigators evaluated how various CVD markers shift after initiation of ART.

Thirty-seven treatment-naive HIV-infected men were randomized to start receiving lopinavir/ritonavir plus either AZT/3TC or nevirapine. Carotid intima-media thickness, arterial stiffness, compliance coefficients, and biomarker levels were measured at baseline and then at 3, 12, and 24 months after treatment initiation.

During the study period, carotid intima-media thickness increased and femoral arterial stiffness decreased in both treatment groups, while compliance coefficients decreased only in the AZT/3TC …

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Mixed Effect of ART on CVD Markers

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Reviewing Author