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Postexposure prophylaxis (PEP) programs are important in all settings, particularly areas with a high prevalence of HIV infection. In this study, investigators describe their experience rolling out a PEP program in one such area in western Kenya. Regardless of the severity or type of exposure reported (occupational or nonoccupational), all individuals received the same 28-day antiretroviral regimen (consisting of d4T+3TC+nevirapine from 2001–2004 and AZT+3TC+lopinavir/ritonavir from 2005 onward).
Ninety-one occupational exposures — mostly involving hollow-bore needle injuries — were reported during the 5-year study. About 85% of individuals presented within 48 hours, as recommended for occupational PEP. More than 90% of the source patients t…