NPEP and High-Risk Behavior

In an Australian cohort, use of nonoccupational postexposure prophylaxis did not increase high-risk behavior, but men who received such prophylaxis remained at high risk for HIV seroconversion.

As biomedical strategies for HIV prevention such as vaccines, microbicides, and preexposure and postexposure prophylaxis (PrEP and PEP) receive increasing attention, many worry that such strategies might increase high-risk behavior. Mathematical modeling has demonstrated that the population-level effect of imperfectly protective biomedical prevention strategies is exquisitely sensitive to their effect on risky behavior (PLoS ONE 2007; 2:e875). Nonoccupational PEP (NPEP — i.e., PEP after sexual or injection-drug-use exposure), in particular, has been found not to increase such behavior (AIDS 2004; 18:787 and J Acquir Immune Defic Syndr 2004; 35:519).

Now, researchers present data from the Health in Men study cohort in Australia — 1427 HIV-neg…

Reviewing Author

Raphael J. Landovitz, MD

NPEP and High-Risk Behavior

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Reviewing Author