Death from Non–AIDS-Related Causes: Another Risk of Immunodeficiency

Non–AIDS-related deaths accounted for more than half of all deaths in this cohort; the risk was reduced with a higher CD4-cell count.

A higher CD4-cell count protects against HIV-related opportunistic infections. Might it also reduce the risk for non-AIDS complications? Investigators from CASCADE — a multinational collaboration involving 23 cohorts of patients with known seroconversion dates — sought to define the relationship between non-AIDS deaths and HIV-related immunodeficiency.

To be eligible, patients had to have been at least 16 years old at the time of seroconversion, with follow-up since January 1996, when potent combination antiretroviral therapy (ART) became widely available. In all, 9858 patients provided 71,230 person-years of follow-up, during which 597 deaths occurred. Three hundred thirty-three (53%) of these deaths were from non–AIDS-related causes, inclu…

Reviewing Author

Paul E. Sax, MD

Disclosures

Consultant/Advisory BoardGilead Sciences; GlaxoSmithKline/ViiV; Merck; Shionogi

Grant/Research SupportNIH; Gilead Sciences; ViiV

Editorial BoardsUpToDate; Clinical Infectious Diseases

Paul E. Sax, MD

Disclosures

Consultant/Advisory BoardGilead Sciences; GlaxoSmithKline/ViiV; Merck; Shionogi

Grant/Research SupportNIH; Gilead Sciences; ViiV

Editorial BoardsUpToDate; Clinical Infectious Diseases

Death from Non–AIDS-Related Causes: Another Risk of Immunodeficiency

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Reviewing Author