HCV infection is associated with increased overall mortality, but not with AIDS-defining events, in HIV-infected patients.
Conflicting reports exist on whether hepatitis C virus (HCV) coinfection influences HIV disease progression. To evaluate this issue, investigators performed a meta-analysis of studies that compared disease progression and mortality between adults with HIV/HCV coinfection and those with HIV monoinfection.
The researchers selected 27 studies that were conducted after the introduction of potent antiretroviral therapy (ART). The studies included approximately 25,000 coinfected patients and 62,000 HIV-monoinfected patients. The percentage of individuals receiving ART ranged from 35% to 100%. Only a small fraction of patients (0–7%) was reported to have received HCV therapy.
Mortality rates during study follow-up were significantly higher among coi…
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)