The few data presented on this topic at the 2010 Retrovirus Conference revealed important differences between the sexes and potential benefits to early, time-limited treatment.
Not much new information was presented on acute and early HIV infection at the 2010 Conference on Retroviruses and Opportunistic Infections. However, two studies were notable.
In AIDS Clinical Trials Group (ACTG) study 5217, patients with early infection were randomized to receive a finite (36-week) course of antiretroviral therapy (ART) or no therapy [Hogan C et al. Abstract 134]. The trial was stopped prematurely because patients in the no-ART arm progressed faster than expected to needing guideline-recommended ART. Nevertheless, the short course of therapy during early infection did modestly delay the need for subsequent initiation of ART.
In a large North American cohort study of individuals with primary HIV infection, women had more-favo…
Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)