Reduced Survival After Serious Non-AIDS Complications

Among HIV-infected patients with relatively high CD4-cell counts, serious non-AIDS complications were more common than AIDS events — and also carried a worse prognosis.

Since effective antiretroviral therapy (ART) became available, the causes of death for people living with HIV have changed dramatically. In this analysis of immunologically stable HIV-infected patients, investigators report the risk of death following both AIDS and non-AIDS complications.

The analysis included 5472 patients from the SMART study and 4111 from the ESPRIT study; median baseline CD4 counts were 597 cells/mm³ and 457 cells/mm³, respectively. Approximately three quarters of the patients were receiving virologically suppressive ART.

AIDS complications occurred in 286 patients, for a rate of 0.7 per 100 person-years. In contrast, serious non-AIDS events (for example, major cardiovascular events, non-AIDS-related malignancies, cirrhos…

Reviewing Author

Paul E. Sax, MD

Disclosures

Consultant/Advisory BoardGilead Sciences; GlaxoSmithKline/ViiV; Merck; Shionogi

Grant/Research SupportNIH; Gilead Sciences; ViiV

Editorial BoardsUpToDate; Clinical Infectious Diseases

Paul E. Sax, MD

Disclosures

Consultant/Advisory BoardGilead Sciences; GlaxoSmithKline/ViiV; Merck; Shionogi

Grant/Research SupportNIH; Gilead Sciences; ViiV

Editorial BoardsUpToDate; Clinical Infectious Diseases

Reduced Survival After Serious Non-AIDS Complications

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Reviewing Author