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Many studies have documented both low bone-mineral density (BMD) and elevated fracture rates among HIV-infected people. In the latest such study, researchers evaluated fracture rates among ambulatory HIV-infected adults participating in a U.S.-based multicenter prospective cohort study (HOPS).
During a median follow-up of 3.8 years, 233 of almost 6000 HOPS participants experienced a first fracture. Age- and sex-standardized rates of fracture per 10,000 persons rose significantly during the study period, from 57.7 in 2000 to 89.9 in 2008. These rates were consistently higher than those estimated for the general U.S. population, which ranged from 25.8 to 40.3 per 10,000 (per a CDC-sponsored national outpatient health registry) and did not chan…