HIV and Some Antiretrovirals Linked to MI Risk

Four antiretrovirals were associated with a twofold increase in risk for acute myocardial infarction: abacavir, efavirenz, lopinavir, and ritonavir.

Cardiovascular disease is a major cause of morbidity and mortality among aging HIV-positive individuals. Standard risk factors are at least partially responsible, but evidence also points to HIV infection and antiretroviral medications as potential contributors.

In this study, 7053 HIV-positive adults in Quebec were identified and matched to 27,681 HIV-negative adults to evaluate whether HIV infection influences risk for acute myocardial infarction (AMI). Among the HIV-positive individuals, 125 with AMI were matched to 1084 without AMI to assess the role of antiretroviral therapy in AMI.

After adjustment for some traditional risk factors (including prior cardiovascular disease, renal failure, and use of lipid-lowering or diabetes drugs), HIV …

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

HIV and Some Antiretrovirals Linked to MI Risk

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Reviewing Author