HIV Drug Resistance in Asia — More Data Needed

Resistance-associated mutations were detected in 13.8% of treatment-naive patients in three Asian countries, but most of the mutations were of questionable clinical relevance.

Given that the options for antiretroviral therapy (ART) are limited in many Asian countries, transmitted drug resistance could have a major influence on treatment outcomes. However, the prevalence of such resistance in Asia remains largely unknown.

Researchers used standard genotyping assays to test for HIV drug resistance–associated mutations (RAMs) in 682 treatment-naive patients initiating ART at any of eight sites in Hong Kong, Malaysia, and Thailand. Most patients were infected with HIV-1 subtype CRF01_AE (78%) or subtype B (16%).

Overall, 13.8% of patients had evidence of at least one mutation that is associated with resistance to nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs…

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

HIV Drug Resistance in Asia — More Data Needed

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Reviewing Author