Significance of Mucosal Translocation

Evidence of mucosal translocation of bacterial antigens was associated with progression of HIV disease.

A disruption of the intestinal mucosal barrier, resulting in mucosal translocation of bacterial byproducts, has been postulated to drive at least some of the immune activation observed in chronic HIV infection. Now, researchers have evaluated whether mucosal translocation predicts HIV disease progression.

The study involved 379 HIV-infected patients with plasma samples stored from when they were treatment-naive with CD4 counts >200 cells/mm³; each also had a known date of infection. Progression events (defined as treatment initiation, a decline in CD4 count to ≤200 cells/mm³, occurrence of an AIDS-defining illness, or death) were tracked for a median 1.6 years after sample collection. During that time, 260 progression events occurred. Patien…

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Significance of Mucosal Translocation

Topics

Reviewing Author