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Traditionally, syphilis testing and screening has involved a nonspecific test such as rapid plasma reagin (RPR) followed if necessary by a confirmatory test such as the Treponema pallidum particle agglutination (TP-PA) assay. Recently, however, laboratories have begun using a treponemal-specific enzyme or chemiluminescence immunoassay (EIA or CIA) for initial screening or testing followed by an RPR, creating a major clinical dilemma: How should one manage a patient who has a positive EIA or CIA result, followed by a negative RPR result? In this study, researchers describe the clinical characteristics and management of syphilis in individuals with discordant syphilis serology results.
The investigators retrospectively reviewed data from more …