Translating HIV Research into Practice: A Look at ACTG 5164

The presentation and publication of major trial findings led to a substantial and fairly rapid change in clinical practice, but targeted local efforts were required to achieve optimal levels of change.

New data from randomized trials are published almost daily, but how quickly are these data incorporated into clinical practice?

In this case study, investigators analyzed the transfer of scientific evidence from the ACTG 5164 trial — which demonstrated significant survival benefits from initiating antiretroviral therapy (ART) during treatment of an acute opportunistic infection (OI) — into routine clinical practice at San Francisco General Hospital (SFGH).

The researchers reviewed data from 162 HIV-infected adults who received a diagnosis of Pneumocystis jirovecii pneumonia (PCP) at SFGH between 2001 and early 2011 and were not receiving ART at the time (median age, 41; 91% men; 46% white; median CD4 count, 49 cells/mm³). Seventy-three percen…

Reviewing Author

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Translating HIV Research into Practice: A Look at ACTG 5164

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Reviewing Author