What Are the Implications of Poor Immunologic Response to ART?

Among patients with virologic suppression, those with initially poor immunologic response continued to have persistently low CD4-cell counts and had an increased risk for morbidity and mortality.

Most HIV-infected patients who achieve virologic success on potent antiretroviral therapy (ART) also experience adequate CD4-cell recovery. However, a small proportion do not, and the clinical implications of this discordant response to treatment have been unclear.

In this retrospective observational study, participants in the Dutch ATHENA cohort who achieved viral loads <500 copies/mL during the first 2 years on ART were divided into four groups based on their CD4 counts at 1 to 2 years (<200, 200–350, 351–500, and >500 cells/mm³). Those with CD4 counts <200 cells/mm³ were considered to have poor immunologic recovery. Outcomes of interest included a composite endpoint (cardiovascular events, AIDS, cancer, cirrhosis, or death), non–AIDS-defi…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

What Are the Implications of Poor Immunologic Response to ART?

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Reviewing Author