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HIV-serodiscordant couples who wish to have children are currently counseled to use sperm washing followed by assisted reproduction technologies (if the male partner is the infected one) or artificial insemination (if the female partner is the infected one). But do these recommendations still make sense for all couples, given the favorable data on pre-exposure prophylaxis in the HPTN 052 and Partners PrEP studies? Dr. Paul Sax enters the debate in his blog HIV and ID Observations.