Adding Maraviroc to Suppressive ART Will Not Boost CD4-Cell Counts

The drug had minimal effect on the low CD4-cell counts of immunologic nonresponders.

Most HIV-infected patients with adequate virologic suppression on antiretroviral therapy (ART) will eventually achieve a near-normal CD4-cell count. However, in 15 to 20 percent of patients, the CD4-cell count fails to rise despite full virologic suppression. Studies have linked this poor immunologic response to a heightened risk for both HIV-related and non–HIV-related disease.

Hoping to provoke an increase in CD4-cell count among immunologic nonresponders, researchers added maraviroc to the regimens of 32 patients who had undetectable viral loads for a median of 3 years but persistently low CD4-cell counts (median, 153 cells/mm³). Most of the patients were white men, and the median age was 50. Coreceptor status was assessed in 18 patients …

Reviewing Author

Abigail Zuger, MD

Disclosures

Nothing to disclose

Abigail Zuger, MD

Disclosures

Nothing to disclose

Adding Maraviroc to Suppressive ART Will Not Boost CD4-Cell Counts

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Reviewing Author