Both HIV Infection and ART Use Associated with Increased Risk for Adverse Birth Outcomes

Use of ART during pregnancy was associated with increased risk for preterm delivery, small size for gestational age, and stillbirth.

Maternal HIV infection increases the risk for adverse birth outcomes, but the differential contribution of antiretroviral therapy (ART) to this risk remains unclear. To explore this issue, researchers reviewed obstetrical records from six hospitals in Botswana during a 2-year period ending in April 2011.

Nearly all the women seen during the study period (>30,000) were tested for HIV infection, with a positivity rate of 30%. Among the HIV-positive women, 51% initiated AZT monotherapy during pregnancy, 24% continued ART from before pregnancy, 13% received no antiretrovirals during pregnancy, and 12% initiated combination ART during pregnancy. The most common regimen received was AZT/3TC + nevirapine.

Maternal HIV infection was significantly ass…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Both HIV Infection and ART Use Associated with Increased Risk for Adverse Birth Outcomes

Topics

Reviewing Author