Tenofovir and the Kidney — a 10-Year Assessment

In a prospective cohort study, use of tenofovir was associated with an appreciable (albeit modest) reduction in renal function.

Tenofovir's potential to cause renal dysfunction is well documented, but the clinical significance and the true magnitude of this side effect — especially with prolonged therapy — remains ill defined.

In a prospective cohort study, researchers in Montreal followed 1043 antiretroviral therapy (ART)-experienced HIV-infected patients (736 tenofovir exposed, 307 unexposed) for a median of 7.9 years. The cumulative incidence of reduced kidney function, as defined by a confirmed drop in estimated glomerular filtration rate (eGFR) to <90 mL/minute/1.73 m², was 15.1%, 31.5%, and 52.3% after 2, 5, and 10 years, respectively, in the tenofovir-exposed group versus 10.3%, 25.9%, and 40.5% in the unexposed group. The cumulative eGFR loss attributable to …

Reviewing Authors

Babatunde E. Edun, MD

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Tenofovir and the Kidney — a 10-Year Assessment

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Reviewing Authors