Improved Rates of Virologic Suppression, but with Wide Geographic Variation

Between 2001 and 2009, the cumulative rate of virologic suppression within 1 year after ART eligibility increased from 55% to 81% overall, but varied greatly by region.

The efficacy of antiretroviral therapy (ART) has improved since the introduction of potent combination regimens in the mid-1990s. In a recent study involving HIV-infected patients from 17 NA-ACCORD cohorts, investigators examined trends and disparities in treatment initiation within 6 months of ART eligibility (defined as a CD4 count <350 cells/mm³ or an AIDS-defining illness) and in virologic suppression (i.e., HIV RNA ≤500 copies/mL) within 1 year of eligibility. Variables analyzed for their effect on time trends included geographic location, patient demographics, CD4-cell count, viral load, and psychosocial factors such as substance use and mental illness.

Among 10,692 ART-eligible individuals, the cumulative incidence of 6-month ART init…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Improved Rates of Virologic Suppression, but with Wide Geographic Variation

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Reviewing Author