HIV and the Kidney — Beyond Tenofovir

In a very large cohort of HIV-infected patients without pre-existing renal impairment, tenofovir, ritonavir-boosted atazanavir, and lopinavir/ritonavir were each independently associated with renal dysfunction.

HIV-infected individuals are at increased risk for renal problems. Although such problems are multifactorial, antiretroviral medications can play a role; clinical trials are often too small or too short to reveal possible subtle or late effects of these agents. Now, investigators have explored the issue in a study involving 22,603 DAD cohort participants who had at least three estimated glomerular filtration rate (eGFR) measurements and a normal baseline eGFR (≥90 mL/min).

During follow-up (median, 4.5 years), a confirmed eGFR drop to ≤70 mL/min occurred in 478 patients (incidence, 4.78 cases/1000 person-years of follow-up). Chronic kidney disease (CKD; defined as an eGFR drop to ≤60 mL/min) developed in 131 (1.33 cases/1000 person-years of …

Reviewing Author

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

Helmut Albrecht, MD

Disclosures

Grant / Research supportHealth Resources and Services Administration; Centers for Disease Control and Prevention

Leadership positions in professional societiesColumbia Medical Society; South Carolina Infectious Diseases Society

HIV and the Kidney — Beyond Tenofovir

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Reviewing Author