Managing C. diff Infection in Adults

Clinical Takeaway

: Expert guidance from the American Gastroenterological Association

An overview of the AGA Clinical Practice Update on Management of Clostridioides difficile infection in Adults: Expert Review (2026)

Background

The landscape of treatment and prevention of Clostridioides difficile infection (CDI) has evolved in recent years. To provide guidance on the latest therapies, the AGA now offers 14 “best practice advice” statements based on expert opinion (without assessment of strength of recommendations or quality of evidence).

Key Recommendations

Diagnosing and Classifying CDI

Use multistep laboratory testing to differentiate colonization from active infection. For patients with a positive PCR but negative toxin in whom clinical suspicion for CDI is high, prescribe empiric treatment.
Severe CDI (accompanied by leukocyt…

Reviewing Author

Rahul B. Ganatra, M.D., M.P.H.

Disclosures

Editorial BoardsThe Curbsiders

Grant Recipient/Research SupportVeterans Health Administration