Does Routine Acetaminophen Use Decrease ICU Delirium?

Patients in intensive care units (ICUs) often experience delirium brought on by pain and opioid therapy. The role of adjunctive agents such as acetaminophen in combating delirium is uncertain. In a retrospective, single-center study of 18,000 adults admitted to a Boston ICU for at least 48 hours between 2015 and 2024, researchers examined whether acetaminophen exposure affected delirium burden. Exposure was defined as at least 2 g daily of oral or intravenous acetaminophen on any ICU day.