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Older adults with multiple comorbidities and polypharmacy frequently are prescribed central nervous system (CNS)-active medications, but these drugs are associated with potential harms in this vulnerable patient population. Using data from a multinational study, investigators analyzed 2000 hospitalized older patients (median age, 79) with at least three chronic medical conditions who were prescribed five or more medications (i.e., polypharmacy) at hospital discharge. One or more CNS-active medications (i.e., opioids; antipsychotics; anxiolytics; sedatives; antidepressants; antimigraine, antiepileptic, antiparkinsonian, and antidementia agents; parasympathomimetics; and antivertigo medications) were prescribed to 60% of patients.